Influence of adding calcium channel blocker verapamil during perfusion for functioning transplanted kidney within 36 months after transplantation (mid term results)
Maciej Nowacki1,2, Zbigniew Zietek1,2, Maciej Kotowski2, Karol Tejchman2, Adam Nowacki2, Jerzy Sieńko2, Jolanta Nawrocka2, Daniel Kotrych2, Ireneusz Wiernicki2, Joanna Stępniewska2, Leszek Domański2, Marek Droździk2, Marek Ostrowski2.
1Department of General Surgery and Transplantation, Pomeranian Medical University in Szczecin, Poland, Szczecin, Poland; 2Department of Vascular Surgery, Pomeranian Medical University in Szczecin, Poland, Szczecin, Poland
Optimal method of preservation is the one of most important problems in organ transplantation. Flushout blood and metabolities, quick decreasing temperature of harvested organ, saving organ vitality are important points for good results of transplantation. In our research we tried to answer how much calcium channel blocker, Verapamil decreases kidney vessel resistance during harvesting and preservation how calcium channel blocker influence for graft after 12, 24 and 36 months after transplantation. Many authors imply that calcium plays central role in the pathogenesis of preservation injury and loss of organ viability. We analized 38 kidney cadaver-donors and 76 transplanted patients. Before starting gravity perfusion we injected intraarterial Verapamil solution directly to the one of the renal artery. We measured on the back table renal flow of perfusion solution (Eurocollins) in one minute each kidney. Patients after kidney transplantation were divided in two groups, first group of patients using intraarterial Verapamil and second group without it. We observed in group of recipients with graft after injecting Verapamil improved graft function after transplantation by measurement diuresis, level of creatinine and urea in 12, 24 and 36 months.
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