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P8.024 Evaluation of function of angiopoietins and ANIOPOIETIN likes in post-transplantation diabetes mellitus (PTDM) in Kuwaiti kidney transplanted patients

Osama Ashry Gheith, Egypt

Mansoura university

Biography

Biography

I am Dr. Osama Ashry Ahmed Gheith, who graduated in 1987 from Mansoura faculty of medicine, Egypt. I have held an MD degree in Internal Medicine and Nephrology since 2003. I have been trained at Mansoura urology and nephrology center, Mansoura University, Egypt from 1991 till 2008 when I join the work at Hamed Al-Essa organ transplant center.

I am a member of the following societies: International Society of Nephrology (ISN), European Dialysis Transplantation Association (EDTA), African Association of Nephrology (AFRAN), Arab Society of Nephrology, and Egyptian Society of Nephrology (ESN).

I have long experience with all nephrology activities including all dialysis modalities, medical care of more than 3500 renal transplant recipients, and surgical Skills of importance in the field of nephrology as vascular access creation, PD catheter insertion, and renal biopsies. Moreover, I am interested in training and supervising Junior Staff in nephrology and renal transplant (in Egypt, Yemen, and Kuwait).

I have completed the NIH Web-based training course “Protecting Human Research Participants”. I am interested in research work and have over 12 research projects ongoing in the department. I am an author and/or co-author of over 85 publications in peer-reviewed international journals. In addition to several abstracts in many Middle East and international conferences. I am interested in the field of immunosuppression in renal transplantation, post-transplant diabetes, infection, and anemia.

I won some of the research prizes with the special concern of Emirates medical association –Nephrology Society EMAN YOUNG INVESTIGATOR AWARD –during the 12th congress of the Arab society of nephrology and renal transplantation 2014, 6th ISN EMAN Update Course in Nephrology 2014, 10-13December 2014 Dubai, UAE; one of the top 5 posters presented in ESNT 2018 (impact of HLA DR mismatch in elderly renal transplant recipients regardless donor sources: single-center experience from the middle east) and one of the top 5 posters presented in ESNT 2019 (Screening for BK viremia/viruria and the Impact of Management of BK Virus Nephropathy in Renal Transplant Recipients).

Abstract

Evaluation of function of angiopoietins and ANIOPOIETIN likes in post-transplantation diabetes mellitus (PTDM) in Kuwaiti kidney transplanted patients

Mohamed Jahromi2, Torki Al-Otaibi 1, Osama Gheith1,3, Nashwa Othman 2,4, Tarek Mahmoud1, Parasad Nair 1, Medhat A-Halim 1, Mohamed Abu Farha2, Jehad Abu Baker2.

1Nephrology , OTC kuwait, Kuwait, Kuwait; 2Education , Dasman Diabetes institute, Kuwait, Kuwait; 3Nephrology , MUNC, mansoura, Egypt; 4Public health, Faculty of nursing , Mansoura, Egypt

Background: Post Transplantation Diabetes Miletus (PTDM) is a chronic metabolic disease developed in some of our kidney transplant patients. PTDM is a chronic, inflammatory disease with a direct impact on patients’ immune system. Angiopoietin and Angiopoietin-like are intrinsic mediators induced by immune cells.

Objectives: To determine the relationship between circulating Angiopoietin-1 and 2 (ANG-1, 2) and Angiopoietin-like (ANGPTL 3-8) in kidney transplant patients who develop diabetes (PTDM) vs. patients who do not develop diabetes(CONTROL) after kidney transplantation.

Methods: In this cross-sectional study, all patients were enrolled from Dasman Diabetes Institute Diabetes Education Department and outpatient clinics of the Hamad Al Essa Organ Transplant Centre of Kuwait between May 2015 and December 2016. The present study included 155 PTDM and 154 controls, age- and sex-matched. We collected 3 ml of venous blood from each subject. Enzyme-linked immunosorbent assay (ELISA) determined plasma ANG 1,2 and ANGPTL 3-8. We determined the correlation between plasma ANG 1 and 2 and ANGPTL3-8 levels in our PTDM and Control group.

Results: In our cohorts, most of the patients (56%) were Kuwaiti. Moreover, the two groups were comparable regarding their original kidney disease, dialysis type, donor type, and the type of both induction and maintenance immunosuppression (P > 0.05). Also, pre-transplant co-morbidities were comparable in both groups, including hypertension, history of exposure to tuberculosis bacilli, ischemic heart disease, bone disease, anemia, and hyperlipidemia (P > 0.05). We found significantly higher plasma ANG-1, ANGPTNL 6, 7, 8 levels in the PTDM group compared to the control group (P < 0.001). However, we found no statistical association between our study groups concerning plasma ANG 2, ANGPTNL 3, 4 (p>0.05).

Conclusion: Plasma ANG 1, ANGPTNL6, 7, 8 levels may correlate with disease severity, chronicity in transplant patients who develop diabetes post Kidney transplantation, and serve as a potential biomarker of the disease severity.

Key Word: Angiopoietin; Angiopoietin Like, Kidney Transplantation, PTDM, ELISA

Presentations by Osama Ashry Gheith

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