Single center study on liver transplantation since 1988: expected life expectancy and affecting factors
Rengin Erdal1, Gulnaz Arslan2, Gokhan Moray3, Sedat Boyacioglu4, Figen Ozcay5, Adnan Torgay2, Mehmet Haberal3.
1Department of Public Health, Baskent University, Ankara, Turkey; 2Department of Anaesthesiology and Reanimation, Baskent University, Ankara, Turkey; 3Department of General Surgery, Division of Transplantation, Baskent University, Ankara, Turkey; 4Department of Gastroenterology, Baskent University, Ankara, Turkey; 5Department of Pediatric Gastroenterology, Baskent University, Ankara, Turkey
Introduction: The purpose of this research paper is to determine the expected life expectancy of liver transplant patients and the factors affecting it.
Materials and Methods: Data of 652 patients who had undergone liver transplantation in the period between December 8, 1988 and December 31, 2021 were analyzed within retrospective cohort study. Surgeries performed by Baskent University team eliminated one of the key factors that would affect the patients’ expected life expectancy in all cases. Dependent variables of the study were defined as cadaveric donor and live donor, whereas the independent variables were defined as age, gender and blood group of donor and recipient, degree of kinship with donor, cancer or other diseases and post-operative complications The data were uploaded to SPSS and applied the Kaplan-Meier, Cox Regression, T-student and Chi-squared tests.
Results: Average life expectancy in cases with a cadaveric donor is 5151 days (14 years), whereas average life expectancy in cases with a live donor is 6268 days (17 years), meaning that there is a statistically significant difference between the two average life expectancies. By gender of recipients is 5,239 days (14 years) for males and 7,459 days (20 years) for females, meaning that there is a statistically significant between the two average life expectancies. The survival distribution in cases where the donor is a parent of the recipient is 7525 days (20 years), whereas 4170 days (11 years) in case of a sibling donor and 3201 days (8 years) in case of other degrees of kinship. When examined by blood group, Rh factors of all recipient groups and donor groups there is no statistically significant between their survival distributions. And there is no statistically significant between the survival distributions of recipients with cancer and those without. When the recipients’ complication distributions are examined, there is a statistically significant between the survival distributions of cases that suffer a perforation or biliary dilatation.
Conclusion: This study revealed that the donor being a cadaveric or live donor, gender of the recipient, their degree of kinship to the donor, post-operative complications had a statistically significant effect on the expected life expectancy of liver transplant patients, while the fact that there is no significant difference between the survival distributions in cases where the donor is cadaveric or a sibling or another degree of kinship makes the practice of sibling donors questionable.
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