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P8.037 Changes in Body Composition after renal transplant in Children

Mara Medeiros, Mexico

Chief
Nephrology and Bone Mineral metabolism Research Unit
Hospital Infantil de México Federico Gomez

Biography

BIOSKETCH

Name: Mara Medeiros Domingo

Medical Degree (MD) obtained at the School of Medicine, National Autonomous University of Mexico; 1984-1989

Research Fellow in Pharmacology: Department of Pharmacology, National Autonomous University of Mexico. Conducted research in Chronopharmacology; 1989.

Residency in Pediatrics, Hospital Infantil de Mexico Federico Gómez, National Autonomous University of Mexico; 1990-1992.

Residency in Pediatric Nephrology, Hospital Infantil de Mexico Federico Gómez, 1993-1995

Certified by the Mexican Council of Nephrology; February 23, 1996. Recertified 2003, 2005.

 

Graduate of Clinical Pharmacology, School of Medicine, National Autonomous University of Mexico (UNAM); March-December 1996.

 

PhD in Biomedical Sciences, National Autonomous University of Mexico; 1997-2000.

 

Post-Doctoral Fellowship. Department of Nephrology/Transplantation Medicine. Weill Medical College of Cornell University. September 2000- October 2003

 

Visting Professor UBC Children’s Hospital Vancouver 2013-2015

email: medeiro.mara@gmail.com

 

Chief of “ Unidad de Investigación y Diagnóstico en Nefrología y Metabolismo Mineral Óseo”, Hospital Infantil de México Federico Gómez

 

Professor of Pharmacology, UNAM

 

Professor Epidemiology postgraduate program, UNAM

 

National Researcher Level III, Sistema Nacional de Investigadores, México

 

President Sociedad Mexicana de Trasplantes

Expresident Instituto Mexicano Investigaciones Nefrológicas

Ex member of ALANEPE Council

 

Research lines

 

Renal transplantation: Rejection biomarkers, pharmacokinetics of immunosuppresants, post-transplant infectious diseases, treatment and prevention of post-transplant metabolic síndrome, treatment of chronic allograft nephropaty.

 

Biomarkers of kidney disease progression.

 

Nutrition and dialysis adequacy in children.

 

Hypertension and AMBP in children.
Bone mineral metabolism in patients with kidney diseases

 

Bioethics in nephrology.          

 

Renal Tubular acidosis

 

Genetics in nephrotoxicity

 

Early detection of kidney diseases in children.

 

 

150 peer-reviewed publications

Abstract

Changes in body composition after renal transplant in children

Mara Medeiros1, Carlos Martínez-Sánchez1, Laura Díaz-Escobar1,2, Lourdes Ortiz-Vásquez1, Patricia Clark-Peralta2, Desiree López-González2.

1Unidad de Investigación en Nefrologia y Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez, Mexico, , Mexico; 2Unidad de Epidemiología Clínica, Hospital Infantil de México Federico Gómez, Mexico, , Mexico

Introduction: Due to the relationship between adipose tissue and cardiovascular outcomes, it is important to monitor the changes in body composition after renal transplant. The aim of the study was to describe the changes in body composition in children during the first-year post- renal transplant.

Methods: We included a cohort of patients aged 5-18 years transplanted between 2014-2017, all signed informed consent/assent. A dual-energy X ray absorptiometry ( DXA) and anthropometric measurement was performed in the first three months after renal transplant and 12 months afterwards. Bone mineral content (BMC, fat mass (FM) , non-bone lean mass (LM) and the index lean mass/Fat mass was calculated to evaluate the proportion of lean mass related to fat.

Results: 50 patients were included, 51% males, 69% adolescents. At baseline low height was found in 78%; by body mass index 69% were normal, 14% had overweight, 4% obesity and 12% were emaciated. By body composition median FM was 26% for female children, 27% for males; in adolescents it was 34% for females and 22% for males. At 12  months the frequency of subjects with normal weight increased to 80%, diminishing the frequency of overweight to 12% and obesity to 2%, only 6% continue emaciated. The changes in the body fat percentage in males was -0.01% whereas in females increased 0.03%, p>0.05.

Conclusions: It is important to evaluate body composition changes in pediatric renal transplant receptors, we found that they continue with low height. No significant changes were found at 12 months in BF- LM in Mexican transplanted -children. Adolescent women tend to acquire more fat.

Financed by Fondos Federales 2014/009.

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