Introduction: Since 2003 a Tissue Banking & Advanced Therapies (TB&AT) training program is offered in the framework of the master’s degree in Donation and Transplantation (University of Barcelona). Since 2011, the program had a blended modular (face to face + on-line) structure: donation, transplantation, management, TB&AT, and Internship (IS). In 2020, due to COVID-19, it was adapted to be online.

Methods: The aim of the study is to describe the experience of the TB&AT program during the 2003-2022 period and analyze the impact of the pandemics on grades and student’s satisfaction. Until 2020, face to face training included an IS, theoretical sessions, simulations, cases debate and group exercises. Since 2021, theoretical sessions have been included in the virtual classroom and practical simulations have been replaced by live sessions. Immersive training (IT) has been employed to substitute IS. For IS, a virtual reality tour to a simulated tertiary Spanish hospital including a donor tissue center.  The TB&AT training is based on the Guide to the Quality and Safety of Tissues and Cells for Human Application of the Council of Europe. Data has been organized in 3 periods, 2003-2010 (1st period), 2011-2020 (2nd period) and 2021-2022 (pandemic period). Participant profiles, grades obtained and the students´ satisfaction has been evaluated.

Results: Since 2003, 1038 participants from 69 countries have attended TB&AT training (411 face to face and 627 on-line).  Students grades evolution are:  8,1/10 (1st period, 7,72/10 (2th period) and 8,24/10 (pandemic period). Participants ‘evaluation in  pandemic period has been 9/10.

Conclusion: Comparative results indicate slight difference in the values, demonstrating stability despite the difficulties by the pandemic The TB&AT training program improves knowledge, technical skills and competence development of the healthcare professionals involved in tissue banking activities. The inclusion of new technologies has been essential to keep offering high quality international educational programs. Further exploring of technologies may also improve efficiency.