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COVID-19 - Outcomes

Wednesday September 14, 2022 - 12:00 to 13:00

Room: C1

410.1 Comparative analysis of kidney transplant recipients with SARS-CoV-2 compared with non-kidney transplant recipients: A largest single center report from the second wave of COVID-19 pandemic in South East Asia.

Sanshriti Chauhan, India

Dr
Nephrology and Transplantation
Institute of kidney disease and research and transplantation sciences

Abstract

Comparative analysis of kidney transplant recipients with SARS-CoV-2 compared with non-kidney transplant recipients: a largest single center report from the second wave of COVID-19 pandemic in South East Asia

Sanshriti Chauhan1, Himanshu Patel1, Subho Banerjee1, Vivek Kute1, Vineet Mishra1, Nauka Shah1, Priyash Tambi1, Ruchir Dave1, Akash Shah1.

1Nephrology and Transplantation, Institute of kidney disease and research center, institute of transplantation sciences, Ahmedabad, India

Introduction: Outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in kidney transplant recipients (KTR) compared with matched cohort is certainly lacking for different pandemic waves and geographic regions.

Methods: In this single-center retrospective study of coronavirus disease (COVID-19) cases admitted from 26 March 2021 to 7 June 2021, a propensity-matched analysis in a 1:1 ratio was performed to compare the clinical profile and outcomes between KTR and non-KTR. A Cox proportional hazard model from the whole study population to analyze risk factors for severe disease and mortality was calculated.

Results: We identified 1052 COVID-19 cases of which 107(10.1%) were KTR. In propensity matched analysis, KTR had higher fever (81.6 % vs 60%; p-value = 0.01), lymphopenia (30% vs 11.7%; p-value = 0.02), higher neutrophil lymphocyte ratio (NLR) (43.3 % vs 25%; p-value = 0.05) and acute kidney injury (AKI) (66.6% vs 36.7%; p-value = 0.001). In Kaplan Meier survival analysis, there was no difference in mortality or severity of COVID-19. In cox hazard proportional analysis European cooperative oncology group score (ECOG) score of 1 to 2(HR (95% Lower CI, Upper CI) = 4.9(1.8-13.5); p-value <0.01], ECOG of > 2[ HR = 20(7.5,54.7); p-value < 0.01] and waitlisted status [HR = 1.9(1.1-3.3); p-value = 0.02] was associated with significant mortality. Kidney transplantation [HR = 0.8(0.47-1.44; p-value = 0.5] was not associated with mortality in the analysis

Conclusions: In our report kidney transplantation status had a different spectrum but was not found independently associated with COVID-19 severity or mortality.

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