Introduction: Diabetes mellitus type 1 and end-stage renal disease can induce low-grade chronic inflammation (LGCI) which has an impact on simultaneous pancreas and kidney transplantation (SPKTx) results, even in carefully qualified recipient.

Objective: To evaluate impact of preoperative LGCI on one-year survival recipients after SPKTx.

Material and methods: Mean observation after SPKTx was 82,7 months (range: 0,1-220). Among 103 SPKTx recipients following parameters of LGCI were assessed directly before transplantation: white blood cells (WBC) [mean: 7,55*103/mm3 (SD±2,56)], neutrophiles (NEU) [mean: 5,12*103/mm3 (SD±2,13)]; platelets (PLT) [mean: 244,3*103/mm3 (SD±84,03)]; C-reactive Protein (CRP) [mean: 4,5 mg/L (SD±4,97)]; albumin (ALB) [mean 4,5(g/dL)  (SD±0,75)]. The markers were categorized using Weight of Evidence test (WoE) supported by Information Value test (IV). Uni- and multivariate analysis was performed with ROC curve and area under curve (AUC) was assessed. Cumulative survivals were assessed using Kaplan-Meier curves.

Results: One-year cumulative survival rates was 87,2 % (SD±0,03). During first year deaths due to complications of infections had significantly higher rate than in second to tenth year after SPKTx (89% vs 11%, Fisher test). ALB, CRP, PLT, WBC and NEU were categorized with cut-off points for further analysis: 3,65g/dL, 2,25mg/L, 180*103/mm3, 8,2*103/mm3 and 5,8*103/mm3, respectively. In univariate analysis significant for 12-month survival were: NEU>5,8*103/mm3, PLT<180*103/mm3, CRP>2,25mg/L and ALB <3,65g/dL with odds ratios (OR): 2,97; 6,75; 5,51; 4,05, respectively. In multivariate analysis, there were two models with independent factors for 12-month survival: model 1 (ALB+PLT) with OR: 3,12 and 5,55; and model 2 (CRP+PLT) with OR: 5,51 and 4,3, respectively. AUC for model 1 and 2 were: 0,74 and 0,759, respectively.

Conclusions: Preoperative recipients LGCI status measured by PLT, ALB and CRP levels have significant impact on one-year survival of SPKTx reicpients.