Objective: To evaluate the intervention strategies for medication compliance of kidney transplantation recipients with nurses' participation systematically, and to provide evidence-based evidence for nursing staff to formulate intervention strategies.

Methods: BMJ Best Practice, UpToDate, Joanna Briggs Institute, The Cochrane Library, Guidelines International Network, Registered Nurses’Association of Ontario, Scottish Intercollegiate Guidelines Network, National Guideline Clearinghouse, PubMed, EmBase, Web of Science, CNKI, WangFang Data. Sinomed were searched to collect evidence of nurse-involved intervention strategies for medication compliance in kidney transplant recipients.The time limit for the retrieval is from the inception of databases until August 7, 2021. 2 researchers screened studies, extracted the data and evaluated the quality of included studies independently.

Results: A total of 22 randomized controlled trials were included in this study.At present, the intervention strategies for medication compliance of kidney transplant recipients with nurses' participation involving clinical pharmaceutical care, behavioral intervention, education, electronic monitoring and reminder, telemedically supported case management, cognitive behavioral therapy, mobile drug manager application, etc.

Conclusion: Nursing staff should pay attention to the poor medication compliance of kidney transplant recipients, more participate in the formulation and implementation of intervention programs actively, and use existing evidence-based evidence to help kidney transplant recipients improve medication compliance. Caregivers could consider cognitive behavioral therapy, behavioral intervention and education intervention strategies, but there is insufficient evidence of existing nurse-involved intervention strategies for medication compliance of kidney transplantation patients , and the selection of the best intervention strategy is difficult and complex. High-quality, large-sample studies are still needed in the future.