HTK vs WISCONSIN and delayed renal graft function
Alfonso Emiliano 1, Álvarez Héctor José María 1, Braccini Mariano Leonardo1, Navarro Tania 1, Segovia José Raúl 1, Fernandez Da Veiga Adrian 1, Lazzeri Silvio Nicolás 1.
1Incucai, Cucaicor, Corrientes, Argentina
Introduction: Preservation solutions are beneficial for solid organ transplants, being an important factor in the development of delayed graft function (RFI), being associated with a reduction in graft survival after one year.
Objectives: To compare the use of histidine-tryptophan-ketoglutarate (HTK) solution vs University of Wisconsin solution with the development of renal graft function delay (RFI).
Material and Method: Observational (Cross Sectional), retrospective and analytical study. Renal transplant patients with cadaveric donors were included during the period between January 2017 and December 2021.T test was used for independent samples and Chi2 2x2 for categorical variables. An alpha value of ≤ 0.05 was determined for statistical significance.
Results: 82 kidney transplant recipients were retrospectively compared with cadaveric, preserved HTK (n=49) and UW (n=33) donors. The mean age of the donors was 40 years. The incidence of RFI was 56%. In the Student test analysis, statistical significance was observed in donor age (37,31 vs 42,52 p= .035), donor BMI (25,78 vs 29,46p= .000), pre-ablation creatinine (0,94 vs 1,18 p= .014) and pre-ablation urea (28,86 vs 39,74 p= .006) and renal RFI. In the CHI2 analysis, the use of HTK solution (KANTRILEX / CUSTOPLEX) was associated with 40.2% renal RFI development (p= .012) (OR 3.17 95% CI 1.26-7.95), compared to UW solution (14.6%) (p=.007) (OR 0.28 CI 95% 0.11-0.71).
Conclusion: In our study, it was observed that the use of HTK solution was associated with a higher risk of renal RFI compared to UW solution.
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