Introduction: The infectological profile of donors is the beginning of the infectological traceability of the donation and transplant process. Complementary studies are positioned as a transcendent source of information, along with clinical examination, especially when the history of donors is unknown. The knowledge of these data allows us to implement various strategies aimed at the quality of care of the recipients and on the other hand allows us to carry out an epidemiological surveillance of the microorganisms prevalent in the different regions of our country. We present the serological profile of donors in Argentina during the period 2017-2021

Methodology: Descriptive and retrospective study. The  donation processes initiated during the period 2017-2021, registered in SINTRA, were selected.  The presence of complete serological studies was considered as an inclusion criterion. The serological memory variables for viruses (HIV, HTLV, CMV, HBV, HCV), bacteria (Treponema pallidum, genus Brucella) and parasites (Trypanosoma cruzi, Toxoplasma gondii) of donors in Argentina during the period were analyzed.

Results: The processes initiated in the period 2017-2021 were 18242.  The processes that documented complete  serological studies were 5889. 85.3% of the donors, during the period analyzed, were from 9 jurisdictions (Buenos Aires, CABA, Santa Fe, Córdoba, Mendoza, Tucumán, Misiones, Entre Ríos and Santiago del Estero).  14.7% corresponds to the rest of the country. From the serological analysis of the donors of the 9 jurisdictions mentioned, cytomegalovirus (89.7%) and Toxoplasma gondii (45.15%) were observed as prevalent serology.   We identified 0.31% of reactive serologies for HIV, 0.23% for HTLV, 0.95% for HCV and 2.74% for Treponema pallidum. In reference to hepatitis B markers, 1.47% of donors presented isolated Ac HBc, the Ac HBc + Ag HBs association was observed in 0.13% and the Ac HBc + Ac HBs association in 2.2%. 1.07% of donors were reactive for Huddleson reaction. 2.94% presented at least 2 reactive serologies for Chagas disease.

Conclusions: The epidemiological surveillance of donors makes it possible to consider possible modifications in the infectological recommendations of the selection of the donor and the follow-up of the recipient.