Summary: In patients with type 1 diabetes mellitus and end-stage renal failure, kidney and pancreas transplantation is the best therapeutic option.

Target: To present the clinical results in patients with type 1 diabetes mellitus and end-stage renal failure who underwent simultaneous kidney and pancreas transplantation.

Materials and methods: Since 2009, 10 kidney and pancreas transplants have been performed at the Almenara hospital, including 10 patients who underwent simultaneous kidney and pancreas transplantation. Non-parametric statistical analysis was performed and survival was estimated using the Kaplan-Meier method.

Results: Between 2009 and 2021, 10 simultaneous kidney and pancreas transplants were performed. The male gender 60%, with an age – at the time of transplantation – of 31 years, and a time elapsed from the start of dialysis support to transplantation of 61 months 70% of the population had dialysis support by hemodialysis 20% peritoneal dialysis and 10% pre-dialysis, Average age of cadaveric donor 25 years, glycemic control was achieved between 24 and 48 hours after surgery. 20% presented delayed function of the renal graft, of this group 50% ended up in graftectomy due to anatomopathological finding, post-reperfusion syndrome associated with thrombosis, survival was 100% per year, and that of the pancreatic graft, 90% per year, values ​​comparable to the best expected results.

Conclusion: Simultaneous kidney and pancreas transplantation is the best surgical option for controlling complications secondary to type 1 diabetes mellitus and end-stage renal failure. The small number of the sample reflects the lack of donors, a situation that worsened with the COVID pandemic.